Recent Update on Dr. Diana Milewicz & Dr. Amy Reid's Ehlers-Danlos Syndrome 2012 - Update on the Smooth Muscle Cells In Vascular Type -


Our research group has been exploring the heterozygous Col3a1 mouse as a disease model for the vascular Ehlers-Danlos syndrome (vEDS).  Human patients harboring similar mutations, namely mutations leading to less type III collagen being made by cells in the body, suffer from complications of vEDS, including problems with the arteries.  This implies that a risk for problems with the arteries may involve deficiency of type III collagen in the artery, which may alter the behavior of cells in the wall of arteries, either the smooth muscle cells or fibroblasts.

We are currently manipulating haploinsufficient Col3a1+/- mice and comparing the results to Col3a1+/+ littermates that possess normal levels of type III collagen, to induce vascular events similar to those occurring in vEDS patients.  At the same time, we are testing the effects of drugs that alter the behavior of the cells in the wall of the artery in these mice.
Visiting Dr. Diana Milewicz lab last August 2011 and  Lynn Sanders (President) EDS Network CARES INC.Dr. Amy Reid, MD PhD Student who is working on our second EDS Research. 

"Role of Smooth Muscle Cells in Vascular Ehlers-Danlos Syndrome"Dr. Reid  is explaining to Michele Heglar (EDS Network CARES Board of Director) and Mary Bryant what all goes into doing research in the lab.Dr. Diana Milewicz's Lab in Houston, Texas.Dr. Reid explaining the whole EDS Research Project to us during our visit. Very exciting results coming from this research. We hope to be able to bring you all the information and results from doing this project, very soon.
Thank you, Dr. Milewicz and Dr. Reid for taking time out of your busy schedule to give us a tour of your lab and for helping us understand our EDS research project. I also would like to thank Dr. Diana Milewicz, Dr. Amy Reid and her staff for caring so much about all our EDS families. We truly appreciate the two of you for wanting to study about  Ehlers-Danlos Syndrome.

This is EDS Network CARES 2nd EDS research project in 6 years. I want to thank all our EDS families for raising money and donating to our cause. 100% of the research money goes to research. Currently, both research projects,are still on going.... One is being done at John Hopkins, with Dr. Hal Dietz and Dr. Diana Milewicz's EDS research is in Houston,Texas. EDS Network CARES gets updates as they are available.

I also would like to give a special thank you to the Ruth Cooper Foundation for helping us make Dr. Milewicz's EDS research happen.with their large donation. We appreciate working together to make it happen, so thank you so much.

Research is a very important part of EDS Network CARES along with Awareness and Support. If you would like to see more research happen,,please continue to send  in your donations or go on our website and pay with paypal (http://www.ehlersdanlosnetwork.org/donations.html). We couldn't do what we are doing, without all our EDS families and friends supporting us.. If your interested in doing a fundraiser.... go to our fundriser page and fill out our fundrising forms..
http://www.ehlersdanlosnetwork.org/Fundraising_For_A_Cure.html  .

Thank you from all of us at Ehlers-Danlos Syndrome Network CARES Foundation
EDS Network CARES Board of Directors
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